Description
Composition:
| Each ml contains-: | |
| Moxifloxacin hydrochloride BP eq. to moxifloxacin | 0.5% |
| Prednisolone Acetate USP | 1.0% |
Pharmacology
Category: Antibiotics+Steroid
Mode of Action:
FREDMOX-PD constitutes 4th generation Fluoro-Quinolones, Moxifloxacin as an anti-bacterial agent. Floro-Quinolones exert their antibacterial effect by preventing bacterial DNA from unwinding and duplicating. Moxifloxacin hydrochloride is a synthetic 8-methoxyfluoroquinolone with a broad spectrum anti-bacterial effect on gram positive, gram negative and other anaerobic micro-organism. Well tolerated with minimal ocular side effects and provides increased penetration into ocular tissues and fluids with improved activity against Streptococci and Staphylococci species. It has a moderate to excellent activity against clinically relevant, gram-negative ocular pathogens.
PREDNISOLONE is a corticosteroid drug with predominant glucocorticoid and low mineralocorticoid activity, making it useful for the treatment of a wide range of inflammatory and used to reduce swelling, redness, itching, and allergic reactions affecting the eye. Corticosteroids inhibit the inflammatory response to a variety of inciting agents and, it is presumed, delay or slow healing.
At molecular level, unbound glucocorticoids readily cross cell membranes and bind with high affinity to specific cytoplasmic receptors. This binding induces a response by modifying transcription and, ultimately protein synthesis to achieve the formation of a protein that inhibits the enzyme phospholipase A2 which is needed to allow the supply of arachidonic acid. The latter is responsible for the formation of the mediators of inflammatory causing mediators.
Thus inhibits the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation with inflammation
Indication and Usage: Post operative inflammations and ocular inflammation related to bacterial infections from the below mentioned strains:
| Corynebacterium species | |
| Micrococcus luteus | Staphylococcus warneri |
| Staphylococcus aureus | Streptococcus pneumoniae |
| Staphylococcus epidermidis | Streptococcus viridans group |
| Staphylococcus haemolyticus | Acinetobacter Iwoffii |
| Staphylococcus hominis | Haemophilus influenzae |
| Haemophilus parainfluenzae | Chlamydia trachomatis |
Precautions:
Hypersensitivity towards any of the component.
Warnings:
- Growth of Resistant Organisms with Prolonged Use
- Avoidance of Contact Lens Wear
- if irritations persist, discontinue the use and consult the eye doctor
- Delays Healing
- Should not be administered in eyes with herpes simplex and fungal infection
- Corticosteroids should not be indicated in corneal ulcers.
- Prolonged use may cause glaucoma or cataract.
Adverse Effect:
Stinging Sensation on instillation, blurry vision, allergic reaction, Irritation in the eye and watery eyes.
Dosage and Administration:
Instill one or two drops in the eye for 2-3 times a day or as directed by the physician
Information to Patient:
Follow the instructions that are provided by your doctor and if the adverse effects persist, discontinue the usage and contact your doctor immediately.
